The Premarket Tobacco Product Application (PMTA) is the FDA review process required before any new tobacco product, including e-cigarettes and vapes, can be legally marketed in the United States. A manufacturer must demonstrate to the FDA that the product is appropriate for the protection of the public health, weighing the benefits to adult smokers who might switch against the risks of youth uptake. The process was created by the 2009 Family Smoking Prevention and Tobacco Control Act. Before 2026, the FDA had authorized only tobacco-flavored and menthol e-cigarettes through PMTA; Glas Inc.'s May 2026 authorization was the first for fruit-flavored products.